COMPOSITIONS AND DOSES OF PEGYLATED URICASE Russian patent published in 2024 - IPC G01N33/53 A61K9/14 A61K38/44 A61K47/50 A61P19/06 A61P3/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the treatment of subjects with hyperuricemia, gout and a condition associated with gout. Disclosed is a method for evaluating a subject for treating hyperuricemia, gout or a condition associated with gout or for preventing aggravation of gout, wherein the method comprises obtaining a uricase antibody titre in a sample from the subject; comparing the uricase antibody titre in the sample from the subject with a threshold value, where the threshold value is a uricase antibody titre equal to 1080; and subject evaluation, where when the level of uricase antibodies is below the threshold value, treatment is indicated or there is no need for adjustment, and when the level of uricase antibodies is above the threshold value, additional monitoring or evaluation is indicated. Also disclosed is a method of treating hyperuricemia, gout or a condition associated with gout, or for preventing aggravation of gout in a subject, as well as a method for preventing aggravated gout.

EFFECT: group of inventions provides evaluation and treatment of a subject with hyperuricemia, gout and a condition associated with gout.

12 cl, 18 dwg, 4 tbl, 4 ex