NOVEL SALT AND MEDICAL APPLICATION Russian patent published in 2017 - IPC C07D417/12 A61K31/427 A61P19/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a tosylate of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulphonamide. Said compound is a crystalline substance and is characterised by x-ray powder diffraction pattern (PXRD), having any three, four, five or six characteristic two-theta (2θ) peaks, selected from a group comprising 9.0, 9.3, 10.0, 10.7, 11.6, 12.5, 12.9, 13.2, 13.8, 14.4, 16.0, 16.6, 17.5, 17.8, 18.1, 21.4 and 23.4° (±0.2° 2θ), when using x-ray radiation CuKalpha1 (wavelength = 1.5406 Å). Invention also relates to use of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2- fluoro-N-(1,3-thiazol-4-yl)benzenesulphonamide tosylate for making a drug for treating pain, preferably, neuropathic, nociceptive, or inflammatory pain, or for treating a disease associated with high uric acid levels in blood.

EFFECT: 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulphonamide tosylate, having better chemical stability and good solubility in water.

10 cl, 8 dwg, 9 tbl, 7 ex