FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to therapeutic treatment of gout and prevention of accompanying side effects and complications in patients. method of prevention and prediction of risk of infusion responses in case of intravenous introduction of pegylated uricase to patients with gout consists in determination of uric acid content in patient's blood serum with the following indication to cessation of therapy at the level of approximately 4 mg/dl. Claimed method also makes it possible to identify risk group of patients, who receive pegylated uricase, with reduction of treatment efficiency due to formation of antibodies and higher risk of infusion response development.
EFFECT: group of inventions provides timely cessation of treatment to prevent infusion responses in patients with gout in treatment with pegylated uricase.
37 cl, 2 tbl, 6 dwg
| Title |
Year |
Author |
Number |
| COMPOSITIONS AND DOSES OF PEGYLATED URICASE |
2020 |
- Dzhonston, Llojd
- Kisimoto, Takasi, Kei
- Sendz, Erl
- Kotrilz, Verner
|
RU2831122C2 |
| VARIANT FORMS OF URATE OXIDASE AND USE THEREOF |
2012 |
- Khartman Yakob
- Mendelovits Simona
|
RU2610680C9 |
| ALTERNATIVE FORMS OF URATE OXIDASE AND USING THEM |
2006 |
- Khartman Jakob
- Mendelovits Simona
|
RU2451074C2 |
| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
- Khartman Jakob
- Mendelovitts Simona
|
RU2435847C2 |
| METHODS AND COMPOSITIONS FOR TREATING HYPERURICEMIA AND METABOLIC DISORDERS ASSOCIATED WITH HYPERURICEMIA |
2012 |
- Ku Mannching Sherri
- Chen Chikh-Kuang
- Lu Vej-Shu
- Lin I-In
|
RU2603050C2 |
| COMBINED USE OF COMPOUND A AND COMPOUND B FOR PRODUCTION OF DRUGS FOR TREATMENT OF GOUT OR HYPERURICEMIA |
2019 |
- Chen, Tszyanven
- Shen, Yan
- Nin, Zhuj
|
RU2783862C1 |
| IMPROVED URICASE SEQUENCES AND TREATMENT METHODS |
2016 |
- Baca Manuel
- Nyborg Andrew C.
|
RU2752497C2 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| NOVEL SALT AND MEDICAL APPLICATION |
2012 |
- Ali Zakhid
- Batcher Kennet Dzhon
- Batt Richard Filip
- Felsted Stefan Dzhon
- Glett Sofi
- Makkernan Rat Mitchell
- Pejnser Mejninder
|
RU2609011C2 |
| URATE OXIDASE CONJUGATES, PHARMACEUTICAL COMPOSITION FOR REDUCTION IN URIC ACID LEVELS AND METHOD FOR PREPARING CONJUGATES STATED ABOVE |
2008 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermen Meri R.
|
RU2443426C2 |
