FIELD: medicine.
SUBSTANCE: present invention relates to immunology. Monoclonal antibody and its fragment are presented, which bind with K11-associated polyubiquitin, characterized by amino acid sequences of hypervariable sections (HVR). Isolated nucleic acid, which codes antibody, according to invention; expression vector; host cell and method of producing antibody are also described. Moreover, immunoconjugate and pharmaceutical composition for treating disease or disorder, containing antibody, according to invention; use of disclosed antibody for preparing drug; method of treating individual, suffering from disease or disorder, selected from cancer, degenerative muscle or nerve disorder; as well as method of determining presence of K11-associated polyubiquitin or polyubiquitinated protein; method of separating K11-associated polyubiquitinated protein and method of determining function and/or activity of K11-associated polyubiquitin are proposed.
EFFECT: present invention can find further application in therapy and diagnostics of diseases, associated with formation of polyubiquitins, containing bond, formed K11 lysine.
46 cl, 9 dwg, 5 tbl, 3 ex
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