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2 603 194

(13)

(51)

IPC

C07F9/59(2006-01-01)

A61K31/66(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2015153965/04, 2015-12-16

(24)

Start date

2015-12-16

(22)

Actual filing date

2015-12-16

(45)

Published

2016-11-27

(72)

Inventor

Klochkov Sergej GeorgievichBrel Valerij KuzmichMakarov Mikhail ViktorovichAnikina Lada VladimirovnaPukhov Sergej Aleksandrovich

(73)

Holder

Establishment Of Russian Academy Of Sciences Institute Of Physiologically Active Compounds Ras Ras)

DIETHYL(3,5-BIS(ARYLIDENE)-4-OXOPIPERIDIN-1-YL)-(ARYL)-METHYLPHOSPHONATES HAVING ANTIPROLIFERATIVE PROPERTIES Russian patent published in 2016 - IPC C07F9/59 A61K31/66 A61P35/00

Abstract RU 2603194 C1

FIELD: chemistry.

SUBSTANCE: invention relates to diethyl(3,5-bis(arylidene)-4-oxopiperidin-1-yl) (aryl)methylphosphonates, which can be used in medicine, of general formula 1:

in which R¹=H, F, OMe; R²=H, F.

EFFECT: are disclosed novel diethyl(3,5-bis(arylidene-4-oxopiperidin-1-yl)(aryl)methylphosphonates with antiproliferative properties and low acute toxicity for treating oncological diseases, including rhabdomyosarcoma, intestinal carcinoma, adenocarcinoma of mammary gland.

5 cl, 1 tbl, 4 ex

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RU 2 603 194 C1

Authors

Klochkov Sergej Georgievich

Brel Valerij Kuzmich

Makarov Mikhail Viktorovich

Anikina Lada Vladimirovna

Pukhov Sergej Aleksandrovich

Dates

2016-11-27—Published

2015-12-16—Filed