COMPOSITION CONTAINING AMYLOIDAL PEPTIDE Aβ-1-6 ATTACHED TO VIRUS-LIKE PARTICLE AND ADJUVANT Russian patent published in 2016 - IPC A61K39/00 A61K47/48 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions refers to pharmaceutics and medicine and concerns a composition for treating and/or preventing dementia, Alzheimer's disease, dementia associated with Alzheimer's disease, or related with the above said diseases conditions, containing 450 mcg of a structure containing peptide Aβ1-6 consisting of a structure of a virus-like particle (VLP) chemically attached to the peptide Aβ1-6 through a divalent linker succinimidyl-6-(b-maleimide propionamido)hexanoate, where the VLP consists of capsid RNA proteins of bacteriophage Qβ and where peptide Aβ1-6 is combined on C-end with the spacer sequence of GGC and with 450 mcg of pharmaceutically acceptable adjuvant, which is a salt of aluminium. In another version the invention is a vaccine, a combination, an application of the composition and a kit.

EFFECT: group of inventions provides at weaker immune reactions decreasing of the rate of microbleedings and treatment at early stages of a disease.

12 cl, 2 tbl, 4 ex