FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to genetic engineering. Recombinant vaccine for prevention viral hepatitis B is disclosed. Vaccine is created on basis of hepatitis B virus surface antigen with mutation G145R (ESC-Ag) produced by cultivation of recombinant yeast strain H. polymorpha KBT-11/pEMmulti-7 or H. polymorpha KBT-12/pEMmono-4, or H. polymorpha KBT-14/pEMmalt-8, or H. polymorpha KBT-14/pEMmono2. Vaccine can contain mixture of ESC-Ag, HBsAg serotype of "ayw" and/or "adw" in equal portions. Vaccine can contain only hepatitis B virus antigen with mutation G145R (ESC-Ag).
EFFECT: prepared vaccines are highly immunogenic, non-toxic, have no side effects.
4 cl, 7 dwg, 1 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT Hansenula polymorpha YEAST STRAIN - PRODUCER OF MUTANT HEPATITIS B VIRUS SURFACE ANTIGEN (VERSIONS) | 2015 |
|
RU2586513C1 |
| RECOMBINANT Hansenula polymorpha YEAST STRAIN - PRODUCER OF HEPATITIS B VIRUS SURFACE ANTIGEN SEROTYPE "ayw" | 2015 |
|
RU2586511C1 |
| RECOMBINANT VACCINE FOR PREVENTING VIRAL HEPATITIS B (VARIANTS) | 2003 |
|
RU2238105C1 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 16 | 2014 |
|
RU2546241C1 |
| RECOMBINANT VACCINE FOR PREVENTION OF VIRAL HEPATITIS E IN ANIMALS | 2012 |
|
RU2501568C1 |
| METHOD FOR OBTAINING RECOMBINANT CORE PROTEIN OF HEPATITIS E VIRUS AND RECOMBINANT VACCINE FOR PROPHYLAXIS OF HEPATITIS E VIRUS | 2012 |
|
RU2501809C1 |
| METHOD OF OBTAINING A RECOMBINANT VACCINE FOR PREVENTION OF HUMANPAPILLOMA VIRUS INFECTION, RECOMBINANT VACCINE | 2018 |
|
RU2681174C1 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 56 | 2014 |
|
RU2546240C1 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 18 | 2014 |
|
RU2546242C1 |
| RECOMBINANT YEAST STRAIN HARSENULA POLYMORPHA - PRODUCER OF THE MAIN CAPCID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 11 | 2018 |
|
RU2676160C1 |
