FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, namely to genetic engineering. What is presented is a recombinant vaccine for the prevention of viral hepatitis E in animals. The vaccine contains a capside protein (rtHEV-ORF2) prepared by culture of the recombinant Hansenula polymorpha yeast strain KBT-11/pHEV-001 containing a DNA sequence integrated into a yeast cell genome and coding a fragment of an amino acid sequence in position 86 to 607 of the capside protein of hepatitis E virus genotype 3 (rtHEV-ORF2) under the control of a MOX gene promoter. The vaccine contains an effective amount of the protein rtHEV-ORF2, an oil adjuvant and a physiologically acceptable solvent.
EFFECT: prepared vaccine is high-immunogenic, non-toxic, and possesses no side effects.
2 cl, 5 ex
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