FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, namely to method of producing granular nanocrystalline hydroxylapatite (GAP). Method of producing granular nanocrystalline hydroxylapatite involves synthesis of hydroxyapatite in saturated solution of calcium hydroxide, decanted after daily settling from settled aggregates of Ca(OH)2, by adding alkali solution of orthophosphoric acid, while stirring constantly, until pH reaction of mixture is above 10, then it is settled, liquid phase is decanted and frozen, obtained colloid solution of high-purity nanohydroxyapatite is freezed in liquophilic chamber, which is preliminary cooled; that is followed by freeze-drying in vacuum at temperature of -5 °C and ready granules are separated into fractions.
EFFECT: described method enables easy and reliable production of granules of nanocrystalline high-purity GAP in range of ½ to 2 mm.
1 cl, 1 dwg, 2 tbl, 6 ex
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