METHOD OF PRODUCING SINGLE-PHASE CRYSTALLINE SILICON-SUBSTITUTED HYDROXYAPATITE Russian patent published in 2016 - IPC C30B29/14 C01B25/32 C01B33/24 A61L27/12 A61L27/32 B82B3/00 B82Y30/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a process of preparation of crystalline silicon-substituted hydroxyapatite (Si-HA), which can be used in orthopedics and dentistry. Si-HA is received by deposition method from extracellular fluid model solution by preparing a solution with the following composition: CaCl₂ - 3.7424 g, MgCl₂ - 0.6092 g, K₂NRO₄ - 2.8716 g, NaHCO₃ - 4.5360 g, Na₂SO₄ - 0.0144 g, NaCl - 8,8784 g at pH 7.40±0.05, by adding to it of modified sodium silicate in a molar ratio of Ca/ (P + Si) 2.00÷2.50 in the shape of Na₂SiO₃, by letting it settle for 48 hours, by filtering, washing and drying at a temperature of 80±5 °C for 5 hours.

EFFECT: invention allows to obtain a monophasic nanocrystalline (with an average crystal size of 6-7 1/10 nm) Si-HA having enhanced bioactivity in a medium that simulates the extracellular fluid of a human body.

1 cl, 5 dwg, 3 tbl