FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, namely to producing aldehyde marked antibody for conjugation with drug of interest, and can be used in medicine. Obtained antibody can be modified with formylglycine-forming enzyme to make 2-formylglycine modified (FGly) antibody, which can be covalently and site specificly is conjugated with target fragment.
EFFECT: invention enables to obtain conjugate, capable of directed delivery in antigen expressing body tissues.
60 cl, 33 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-CD22 ANTIBODY-MAITANSIN CONJUGATES AND METHODS OF THEIR APPLICATION | 2016 |
|
RU2744895C2 |
| CELL THAT PRODUCES ACTIVE PROTEIN ARYL SULFATASE B WITH HIGH EFFICIENCY, AND METHOD FOR OBTAINING THIS CELL | 2020 |
|
RU2763990C2 |
| GLYCOSYLATED CONGUGATES OF MOLECULES WITH REPEATING MOTIF | 2010 |
|
RU2574201C2 |
| NEUROTOXINS SHOWING SHORTENED BIOLOGICAL ACTIVITY | 2012 |
|
RU2646110C2 |
| IMPROVED METHODS OF PRODUCING RECOMBINANT POLYPEPTIDE | 2014 |
|
RU2711322C1 |
| MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN-31 | 2012 |
|
RU2588462C2 |
| PRODUCING ACTIVE HIGHLY PHOSPHORYLATED HUMAN LYSOSOMAL SULPHATASE ENZYMES AND USE THEREOF | 2009 |
|
RU2510820C2 |
| CANINISED MURINE ANTIBODIES TO HUMAN PD-1 | 2014 |
|
RU2676158C1 |
| LIBRARY OF CONCENTRATION-DEPENDENT ION BINDING MOLECULES | 2012 |
|
RU2812861C1 |
| PRODUCTION OF ACTIVE HIGHLY PHOSPHORYLATED N-ACETYLGALACTOSAMINE-6-SULPHATASE AND USE THEREOF | 2011 |
|
RU2607376C2 |
