FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, namely to producing aldehyde marked antibody for conjugation with drug of interest, and can be used in medicine. Obtained antibody can be modified with formylglycine-forming enzyme to make 2-formylglycine modified (FGly) antibody, which can be covalently and site specificly is conjugated with target fragment.
EFFECT: invention enables to obtain conjugate, capable of directed delivery in antigen expressing body tissues.
60 cl, 33 dwg, 3 ex
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