METHOD OF MEASURING ABSORBED DOSE IN BORON NEUTRON CAPTURE THERAPY OF MALIGNANT TUMORS Russian patent published in 2017 - IPC A61N5/10 A61K51/00 A61K101/02 A61K103/20 A61P35/00 

FIELD: medicine.

SUBSTANCE: method relates to nuclear medicine, neurooncology, can be used in boron neutron capture therapy (BNCT) of malignant tumors. Performed an introduction to the patient a preparation of targeted delivery of boron, irradiating by the flow of epithermal neutrons and measurement of gamma-spectrometer spatial distribution of radiation intensity of gamma-quanta. Note here that preliminary preparation of targeted delivery is marked with stable atomic nucleus, which under irradiation by epithermal neutrons is activated and splits with electron emission. At the same time for measuring of spatial distribution of the absorbed dose is calculated ratio of intensity of activation of stable atomic nucleus to intensity of neutron absorption with boron, using measurement of ratios of boron concentrations and target nucleus for radiation capture of neutrons and measurement induced activity after irradiation. Gamma-spectrometer can be located outside the room, where irradiation is carried out. As a reagent with a stable atomic nucleus, activated under action of epithermal neutrons is used gold or indium.

EFFECT: method provides the accurate determination of the absorbed dose of neutrons and its spatial distribution in the tumor.

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