METHOD FOR DETERMINATION OF THE ABSORBED DOSE OF RECOIL NUCLEI Russian patent published in 2021 - IPC A61N5/10 C12N5/02 

FIELD: biotechnology

SUBSTANCE: invention relates to the field of biotechnology, namely, to the determination of the absorbed dose of recoil nuclei, as the sum of the doses of fast neutrons and thermal neutrons. The method includes irradiation of cell cultures with γ-radiation and mixed radiation (γ-radiation and neutron radiation). Next, the determination of γ-radiation D_γ dose, leading to the same magnitude of cell survival, and determination of the absorbed dose of recoil nuclei D_n from the ratio D_n=Dγ _standard –D_{γ mixed} are carried out, where D_n is absorbed dose of recoil nuclei, g eq.; D_{γ standard} is dose of γ-radiation when cells are irradiated with γ-radiation, g; D_{γ mixed} is dose of γ-radiation when cells are irradiated with mixed radiation, g.

EFFECT: invention makes it possible to measure the absorbed dose of recoil nuclei - the sum of the doses of fast neutrons and thermal neutrons - necessary for planning boron-neutron capture therapy for malignant tumors.

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