METHOD FOR DELIVERY OF BORON-CONTAINING PREPARATIONS FOR BORON NEUTRON CAPTURE THERAPY Russian patent published in 2016 - IPC A61K33/22 A61K9/127 A61P35/00 

Abstract RU 2589822 C2

FIELD: medicine.

SUBSTANCE: invention relates to method for delivery of boron-containing preparations (10B) for boron neutron-capture therapy (BNCT), for delivery of boron-containing preparations into cells using pegylated liposomes. At that, when preparing liposomes, additionally luminescent dye of one colour is introduced into lipid part of liposomes, and luminescent dye of another colour - into aqueous part of liposomes, and control of delivery into cell is carried out by comparing images obtained in both colours with help of fixing device.

EFFECT: invention provides high reliability of delivery of boron-containing preparations for BNCT inside tumour cells, and can enable both determination of intracellular boron concentration in different moments of time and determination of maximum intracellular boron concentration required to achieve maximum effect from BNCT.

7 cl, 4 dwg

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RU 2 589 822 C2

Authors

Taskaev Sergej Yurevich

Kanygin Vladimir Vladimirovich

Mukhamadiyarov Rinat Avkhadievich

Kichigin Aleksandr Ivanovich

Dates

2016-07-10Published

2014-12-02Filed