Patenton — panteon of patents

(19)

RU

(11)

2 606 510

(13)

C2

(51)

IPC

C07D231/20(2006-01-01)

A61K31/415(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2013118209, 2011-09-12

(24)

Start date

2011-09-12

(22)

Actual filing date

2011-09-12

(45)

Published

2017-01-10

(72)

Inventor

Spajvi MarkSatokh TakasiKarlson Dzhonatan Erik

(73)

Holder

Ejsaj Ar End Di Menedzhment Ko., Ltd.

PHARMACEUTICAL COMPOSITION Russian patent published in 2017 - IPC C07D231/20 A61K31/415 A61P29/00 A61P35/00 A61P25/28 

Abstract RU 2606510 C2

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to compounds of formula (I), in which one of R1a and R1b is hydrogen and the other is methyl; or R1a and R1b together form a cyclopropyl ring; R2 denotes methyl or monofluoromethyl, difluoromethyl or trifluoromethyl; R3 denotes methyl; R4 denotes hydrogen, halogen, monofluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy, monofluoromethoxy, difluoromethoxy or trifluoromethoxy; R5 denotes hydrogen, halogen, monofluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy, monofluoromethoxy, difluoromethoxy or trifluoromethoxy; R6 is hydrogen; R7 means hydrogen; and X denotes oxygen; or pharmaceutically acceptable salts thereof.

EFFECT: compound of formula (I) inhibit the transmission of PGE/EP4 signal and can be used for treating autoimmune pathologies, such as rheumatoid arthritis, multiple sclerosis, psoriasis, cancer and other; invention also relates to pharmaceutical compositions containing these compounds, and methods for using them in the case of individuals in need of treatment.

50 cl, 2 dwg, 3 tbl, 113 ex

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RU 2 606 510 C2

Authors

Spajvi Mark

Satokh Takasi

Karlson Dzhonatan Erik

Dates

2017-01-10—Published

2011-09-12—Filed

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