METHOD FOR PREVENTING THE DEVELOPMENT OF MYOCARDIAL INFARCTION IN MICE WITH MELANOMA THAT DEVELOPED AGAINST THE BACKGROUND OF CHRONIC NEUROGENIC PAIN Russian patent published in 2022 - IPC G09B23/28 A61K35/34 A61P9/10 

Abstract RU 2786322 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental oncology. Male C57BL/6 mice are initially treated with chronic neurogenic pain. After 2 weeks, a suspension of B16/F10 murine melanoma tumor cells in 0.5 ml of saline at a dilution of 1:20 is injected subcutaneously under the scapula on the left. 24 hours after inoculation of B16/F10 melanoma, mice are intraperitoneally injected with freshly isolated mitochondria from the heart of intact rats: 3.3 mg of protein per 1 animal in 0.3 ml of saline, then mitochondrial therapy is carried out daily for 21 days.

EFFECT: invention prevents the development of myocardial infarction.

1 cl, 5 dwg, 1 tbl

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RU 2 786 322 C1

Authors

Kit Oleg Ivanovich

Frantsiiants Elena Mikhailovna

Shikhliarova Alla Ivanovna

Neskubina Irina Valerevna

Kaplieva Irina Viktorovna

Kachesova Polina Sergeevna

Bandovkina Valeriia Akhtiamovna

Trepitaki Lidiia Konstantinovna

Pogorelova Iuliia Aleksandrovna

Cheriarina Natalia Dmitrievna

Ishonina Oksana Georgievna

Dates

2022-12-20Published

2022-05-06Filed