FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Invention describes antisense oligonucleotides, modulating expression of sex hormones binding globulin (SHBG), in particular by targeted interaction with natural antisense polynucleotides of sex hormones binding globulin (SHBG). Present invention also relates to use of such antisense oligonucleotides for treating diseases and disorders, associated with SHBG expression. Said oligonucleotides have length from 19 to 30 nucleotides, wherein they are specifically hybridized with natural antisense polynucleotide of SHBG gene and have sequence identical at least by 90 % to sequence reverse complementary to section within from 1 to 3016 nucleotide of sequence SEQ ID NO: 2 or within from 1 to 1609 nucleotide of sequence SEQ ID NO: 3, or have sequence, identical at least by 90 % to section of sequence SEQ ID NO: 1, wherein they can optionally contain one or more modifications, selected from following: at least one modified sugar fragment, at least one modified internucleoside link, at least one modified nucleotide and their combinations.
EFFECT: invention extends range of products for treating diseases and disorders, associated with SHBG expression.
32 cl, 1 dwg, 2 ex
