FIELD: medicine, pharmacy.
SUBSTANCE: invention refers to biochemistry. Oligonucleotides with length of 15 - 30 nucleotides are described, that specifically hybridize to natural antisense IRS2 sequence and have a sequence similar to the one inversely complementary with the portion of SEQ ID NO: 3 sequence by at least 80%, have a sequence similar to the portion of SEQ ID NO: 1 sequence by at least 80%, wherein the said oligonucleotides optionally contain one or more modifications selected from the following: at least one modified sugar unit, at least one modified internucleoside linkage, at least one modified nucleotide and combinations thereof; and their application for treatment of diseases and disorders associated with the expression of UCP2.
EFFECT: invention expands the arsenal of tools for treatment of diseases and disorders associated with the expression of UCP2.
28 cl, 1 dwg, 2 ex
