FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Invention describes antisense oligonucleotides, modulating expression of nuclear respiratory factor 1 (NRF1), in particular by targeted interaction with natural antisense polynucleotides of nuclear respiratory factor 1 (NRF1). Wherein antisense oligonucleotide is oligonucleotide with length from 19 to 30 nucleotides, which is specifically hybridized with natural antisense polynucleotide of NRF1 and has sequence, at least 90 % identical to sequence, back complementary to section within 1 to 810 nucleotide of sequence SEQ ID NO: 2, or has the sequence, at least at 90 % identical to the section of the sequence SEQ ID NO: 1, wherein said oligonucleotide optionally contains one or more modifications, selected from: at least one modified sugar fragment; at least one modified internucleotide linkage; at least one modified nucleotide; and their combinations. Invention also relates to their application for treating diseases and disorders associated with expression of NRF1.
EFFECT: invention enables increasing gene expression of nuclear respiratory factor 1.
30 cl, 1 dwg, 2 ex
