FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to biochemistry, namely to an antibody or fragment thereof, wherein the antibody or fragment thereof specifically binds to CAPRIN-1 protein, DNA, its encoder, as well as to a conjugate of the said antibody or fragment thereof with an antitumor agent. The invention also relates to pharmaceutical composition and pharmaceutical combination for cancer treatment or prevention, in which CAPRIN-1 is expressed on the malignant cell surface, as well as to a method for cancer treatment or prevention, in which CAPRIN-1 is expressed on the malignant cell surface using the above antibody or fragment thereof.
EFFECT: invention enables efficient cancer treatment or prevention, in which CAPRIN-1 is expressed on the malignant cell surface.
8 cl, 7 ex
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