FIELD: pharmacology.
SUBSTANCE: invention relates to an antibody or a binding fragment thereof, wherein the antibody or a binding fragment thereof specifically binds CAPRIN-1 protein and has immunological reactivity to CAPRIN-1 protein, its encoding DNA, and also to a pharmaceutical composition for treatment or prevention of cancer, expressing CAPRIN-1, and to a conjugate capable of specifically binding CAPRIN-1 protein. A method of treatment or prevention of cancer expressing CAPRIN-1 using the aforementioned antibody or fragment thereof and to a pharmaceutical combination for treatment or prevention of cancer expressing CAPRIN-1, comprising the aforementioned pharmaceutical composition and a pharmaceutical composition comprising an antitumor agent, are described as well.
EFFECT: invention enables efficient treatment or prevention of cancer expressing CAPRIN-1.
8 cl, 7 ex
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