FIELD: biotechnology.
SUBSTANCE: invention relates to compounds constituting hydrazine thiazole usnic acid derivatives of general formula I, wherein Rα is pinene, phenyl, 4-fluorophenyl, 4-hydroxyphenyl, 4-methoxyphenyl or 3-methoxy-4-hydroxyphenyl substituents. According to the invention, the compounds exhibit the ability to inhibit human tyrosyl-DNA-phosphodiesterase 1 (Tdp1) enzyme action.
EFFECT: Tdp1 inhibitor based on hydrazine thiazole derivatives of usnic acid.
1 dwg, 1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2-ACETYL-6-(2-(2-(4-BROMBENZYLIDENE)HYDRAZINYL)THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIOBENZO[B,D]FURAN-1(9BH)-OH, WITH INHIBITING ACTION ON HUMEN TYROSYL-DNA-PHOSPHODIESTERASE 1 | 2016 |
|
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|
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| MEANS FOR HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME INHIBITION | 2015 |
|
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