FIELD: biochemistry.
SUBSTANCE: invention relates to molecular biology, biochemistry, biotechnology and chemical-pharmaceutical industry, and represents an agent, which is one of enamine derivatives of usnic acid of general formula I; 
, where R - an aromatic substitute, which contains a halogen or hydroxy and tert-butyl substitutes, attached to the nitrogen atom directly or via ethyl or propyl linker, showing inhibitory activity against enzyme tyrosyl-DNA-phosphodiesterase of 1 person.
EFFECT: invention provides increasing of inhibitory activity on enzyme tyrosyl-DNA-Phosphodiesterase of 1 person (Tdp1) and wider range of inhibitors of this enzyme.
1 cl, 1 dwg, 1 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HYDRAZINE THIAZOLE DERIVATIVES OF USNIC ACID WITH INHIBITORY ACTION TOWARDS HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2015 |
|
RU2612256C1 |
| 2-ACETYL-6-(2-(2-(4-BROMBENZYLIDENE)HYDRAZINYL)THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIOBENZO[B,D]FURAN-1(9BH)-OH, WITH INHIBITING ACTION ON HUMEN TYROSYL-DNA-PHOSPHODIESTERASE 1 | 2016 |
|
RU2627764C1 |
| AGENT FOR INHIBITING HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2014 |
|
RU2581060C1 |
| AGENTS FOR INHIBITING ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON BILE ACIDS | 2018 |
|
RU2689335C1 |
| ADAMANTYL-CONTAINING DERIVATIVES OF 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE HAVING MONOTERPENOID FRAGMENTS USED AS INHIBITORS OF THE ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 | 2020 |
|
RU2761880C1 |
| MEANS FOR HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME INHIBITION | 2015 |
|
RU2612875C1 |
| FURILIDENE FURANONE DERIVATIVES OF USNIC ACID AS NEW ANTITUBERCULOSIS AGENTS | 2013 |
|
RU2533707C1 |
| 1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS | 2019 |
|
RU2697409C1 |
| 1,1'-(HEXANE-1,6-DIYL)BIS(3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTAREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES TEMOZOLOMIDE ACTIVITY ON GLIOBLASTOMA CELLS | 2019 |
|
RU2724882C1 |
| AGENT FOR INHIBITING THE HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME BASED ON PENTAFURANOSYL NUCLEOSIDE DERIVATIVES | 2019 |
|
RU2748103C1 |
