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IPC

C07D417/04(2006-01-01)

A61K31/427(2006-01-01)

(21) (22)

Application

2016132716, 2016-08-08

(24)

Start date

2016-08-08

(22)

Actual filing date

2016-08-08

(45)

Published

2017-08-11

(72)

Inventor

Luzina Olga AnatolevnaZakharenko Aleksandra LeonidovnaSokolov Dmitrij NikolaevichSalakhutdinov Nariman FaridovichLavrik Olga IvanovnaKhazanov Veniamin Abramovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdeleniya Rossijskoj Akademii Nauk So Ran)Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamentalnoj Meditsiny Sibirskogo Otdeleniya Rossijskoj Akademii Nauk So Ran)Obshchestvo S Ogranichennoj Otvetstvennostyu Farmakologicheskie Razrabotki"

2-ACETYL-6-(2-(2-(4-BROMBENZYLIDENE)HYDRAZINYL)THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIOBENZO[B,D]FURAN-1(9BH)-OH, WITH INHIBITING ACTION ON HUMEN TYROSYL-DNA-PHOSPHODIESTERASE 1 Russian patent published in 2017 - IPC C07D417/04 A61K31/427

Abstract RU 2627764 C1

FIELD: biotechnology.

SUBSTANCE: compound is 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one of formula

. The compound of the invention shows the ability to inhibit the action of the human tyrosyl-DNA-phosphodiesterase 1 (Tdp1) enzyme.

EFFECT: derivative of usnic acid as a human tyrosyl-DNA phosphodiesterase 1 enzym inhibitor and an increased inhibitory effect on the Tdp1 enzyme.

2 dwg, 3 ex

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RU 2 627 764 C1

Authors

Luzina Olga Anatolevna

Zakharenko Aleksandra Leonidovna

Sokolov Dmitrij Nikolaevich

Salakhutdinov Nariman Faridovich

Lavrik Olga Ivanovna

Khazanov Veniamin Abramovich

Dates

2017-08-11—Published

2016-08-08—Filed