PEMPHIGUS SIMULATION METHOD FOR MICE BY IMMUNOGLOBULIN G ADMINISTRATION Russian patent published in 2017 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: method comprises administering of immunoglobulin G (IgG) preparation, taken from patients with pemphigus vulgaris to newborn mice. Here IgG is taken from at least 5 patients. The resulting preparation is administered in a dose of 30 mg of IgG/mouse followed by animal euthanasia after 48 hours. The method can be reproduced in 100% of cases and provides clinical, histological and immunological features of pemphigus, which is important for the study of pathogenetic mechanisms of the disease and the development of new methods of severe autoimmune dermatosis diagnosis and treatment.

EFFECT: method is effective for establishment of an experimental pemphigus model in order to obtain the possibility of pathogenesis study, development of new methods of pemphigus diagnosis and treatment.

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