Show metadata Hide metadata

(19)

(11)

2 616 507

(13)

(51)

IPC

G01N33/50(2006-01-01)

C12Q1/68(2006-01-01)

A61F2/24(2006-01-01)

(21) (22)

Application

2016103236, 2016-02-01

(24)

Start date

2016-02-01

(22)

Actual filing date

2016-02-01

(45)

Published

2017-04-17

(72)

Inventor

Ponasenko Anastasiya ValerievnaKhutornaya Mariya VladimirovnaKutikhin Anton GennadevichRutkovskaya Natalya VitalevnaBarbarash Leonid Semenovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Kompleksnykh Problem Serdechno-Sosudistykh Zabolevanij" Kpssz)

METHOD OF PREDICTING RISK OF CALCIFICATION OF BIOLOGICAL PROSTHESIS OF HEART VALVES, IMPLANTED IN MITRAL POSITION, BASING ON GENOMIC PREDICTORS Russian patent published in 2017 - IPC G01N33/50 C12Q1/68 A61F2/24

Abstract RU 2616507 C1

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine and is intended for prediction of risk of calcification of biological prosthesis of heart valves, implanted in mitral position. Genetic profile of patient is analysed by genes VDR and IL6R, building of prognostic model with application of point evaluation of risk factors, such as male sex, presence in patient's blood serum of polymorphisms of genes VDR rs2228570 and rs731236 and IL6R rs2229238, and to each criterion evaluation point is assigned. On the basis of summary value of indices probable risk of calcification of biological prosthesis is evaluated. If the sum of points is from 0 to 1.5 minimal risk of calcification is predicted, from 1.5 to 3.0 points - medium risk, from 3.0 to 6.0 - high risk.

EFFECT: invention ensures effective prediction of calcification of bioprosthesis of heart valves, placed in mitral position, due to determination of polymorphisms of genes-candidates and calculation of summary risk by evaluation scale.

7 tbl, 3 ex

Similar patents RU2616507C1

Title	Year	Author	Number
METHOD FOR ASSESSING ACTIVITY OF SCLERO-DEGENERATIVE PROCESSES OF BIOPROSTHESES OF HEART VALVES	2023	Maistrenko Aleksei Dmitrievich Ivanova Anna Aleksandrovna Ryzhkova Daria Viktorovna Maistrenko Dmitrii Nikolaevich Stanzhevskii Andrei Alekseevich Molchanov Oleg Evgenevich Murtazalieva Patimat Murtazalievna Nikolaev Dmitrii Nikolaevich Popova Alena Aleksandrovna Gordeev Mikhail Leonidovich Evtushenko Vladimir Ivanovich Generalov Mikhail Igorevich Kokorin Denis Mikhailovich Artemov Maksim Vladimirovich Polysalov Vladimir Nikolaevich Mus Viktor Fedorovich	RU2816076C1
METHOD FOR PREDICTION OF RISK OF CALCIFICATION OF BIOLOGICAL PROSTHESES OF CARDIAC VALVES	2015	Rutkovskaya Natalya Vitalevna Kagan Elena Sergeevna Gruzdeva Olga Viktorovna Khryachkova Oksana Nikolaevna Barbarash Olga Leonidovna Barbarash Leonid Semenovich	RU2597564C1
METHOD OF MAKING VALVE BIOPROTESIS OF HEART VALVE ON FLEXIBLE BASE FRAMEWORK WITH LOW PROFILE	2017	Bajkova Darya Aleksandrovna Zajtsev Ivan Leonidovich Pozdnyakov Sergej Evgenevich Semin Roman Borisovich	RU2698983C2
METHOD FOR MITRAL VALVE THORACOSCOPIC TRANSCATHETER REPROTHESIS BY SELF-DEPLOYING BIOLOGICAL PROTHESIS (VERSIONS)	2016	Bogachev-Prokofev Aleksandr Vladimirovich Zhuravleva Irina Yurevna Zheleznev Sergej Ivanovich	RU2632540C1
METHOD FOR PREVENTION OF LOW CARDIAC OUTPUT SYNDROME AND COMPLICATIONS THEREOF FOLLOWING CARDIAC VALVE REPLACEMENT	2012	Kokorin Stanislav Gennad'Evich Plotnikov Georgij Pavlovich Grigor'Ev Evgenij Valer'Evich Shukevich Dmitrij Leonidovich Sumin Aleksej Nikolaevich Khaes Boris L'Vovich Barbarash Leonid Semenovich	RU2512745C1
MULTIVALVULAR MITRAL AND AORTIC DISEASE SURGICAL CORRECTION COMBINED WITH ACTIVE INFECTIVE ENDOCARDITIS	2006	Karas'Kov Aleksandr Mikhajlovich Semenov Igor' Ivanovich Zhelezchikov Vladimir Evgen'Evich Astapov Dmitrij Aleksandrovich	RU2355327C2
METHOD FOR SURGICAL TREATING AORTAL HEART FAILURE OF INFECTIOUS ETIOLOGY	2001	Karas'Kov A.M. Semenov I.I. Zhelezchikov V.E. Barbarash L.S. Zhuravleva I.Ju. Gantimurova I.L.	RU2218096C2
TRANSCATHETER THORACOSCOPIC METHOD FOR MITRAL VALVE REPLACEMENT IN PATIENTS WITH EXTREME RISK OF SURGICAL TREATMENT (OPTIONS)	2017	Bogachev-Prokofev Aleksandr Vladimirovich Zhuravleva Irina Yurevna Zheleznev Sergej Ivanovich	RU2675068C1
METHOD FOR PREDICTION OF RISK OF MULTIPLE ORGAN FAILURE SYNDROME DEVELOPMENT IN PATIENTS AFTER HEART BYPASS	2017	Ponasenko Anastasiya Valerievna Khutornaya Mariya Vladimirovna Kutikhin Anton Gennadevich Grigorev Evgenij Valerevich Radivilko Artem Sergeevich Zhidkova Irina Igorevna Shukevich Dmitrij Leonidovich Barbarash Olga Leonidovna	RU2641033C1
METHOD OF MITRAL VALVE REPLACEMENT WITH AUTOPERICARDIUM	2022	Komarov Roman Nikolaevich Chernyavskij Stanislav Vyacheslavovich Ismailbaev Alisher Makkamdzhanovich Tkachev Maksim Igorevich Drakina Olga Viktorovna Tsaregorodtsev Anton Vladimirovich	RU2804993C1

RU 2 616 507 C1

Authors

Ponasenko Anastasiya Valerievna

Khutornaya Mariya Vladimirovna

Kutikhin Anton Gennadevich

Rutkovskaya Natalya Vitalevna

Barbarash Leonid Semenovich

Dates

2017-04-17—Published

2016-02-01—Filed