METHOD FOR PREDICTION OF RISK OF CALCIFICATION OF BIOLOGICAL PROSTHESES OF CARDIAC VALVES Russian patent published in 2016 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to transplantology and cardiovascular surgery, and can be used for prediction of risk of calcification of biological prostheses of cardiac valves. If the period of operation of the prosthesis is less than 4 years, the following is to be determined for the patient: sex, age, value of serum concentration of alkaline phosphatase, level of bone isoenzyme of alkaline phosphatase, duration of operation of the biological prosthesis in years. Probable risk (P) of calcification is determined by formula. If P is equal to 0-0.5, low risk of calcification is predicted. If P is from 0.5 to 0.6 - average risk. If P values are within 0.6-1.0, high risk of the implant calcification is probable. If the period of operation of the prosthesis from 4 to 8 years, to be determined are: value of serum osteocalcin of the patient, level of parathyroid hormone, phosphorus content in blood serum. Probable risk (P) of calcification is determined by formula. Low risk of calcification is predicted if P values are from 0 to 0.3. Average risk is predicted if P is within 0.3-0.5. To the high-risk group patients join with P values of 0.5-1. If the period of operation of the prosthesis is more than 8 years, to be determined are: phosphorus content in blood serum, value of calcium-phosphorus ratio, level of bone isoenzyme of alkaline phosphatase. Probable risk (P) of calcification is determined by formula, and low risk is predicted if P is within 0-0.4. Average risk stands for P within 0.4-0.6. High risk of calcification stands for P from 0.6 to 1.0.

EFFECT: group of inventions allows precise prediction of risk of calcification of biological prostheses of cardiac valves by assessing the most significant parameters.

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