FIELD: medicine.
SUBSTANCE: expression levels of TLR4 and TLR9 Toll-like receptor genes, HBD1 antimicrobial peptide gene are determined in the peripheral blood leukocytes of a pregnant women on 5-11 weeks of gestation using a real time polymerase chain reaction. If the defined parameters reduce at least 2.5-fold simultaneously, compared to their level determined at physiological pregnancy, risk of abortion in the first trimester of gestation is predicted.
EFFECT: invention application allows prevention of complications arising from invasive studies, while ensuring the accuracy of prediction of miscarriage of infectious genesis at early stages of gestation due to application of peripheral blood leukocytes as the biological material.
1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF PRETERM DELIVERY OF INFECTIOUS GENESIS | 2009 |
|
RU2408014C2 |
| METHOD FOR PREDICTION OF PRETERM DELIVERY AT GESTATION PERIOD OF 24-34 WEEKS | 2017 |
|
RU2670672C1 |
| METHOD FOR PREDICTION OF MISCARRIAGE OF INFECTIOUS GENESIS AT EARLY STAGES OF GESTATION | 2016 |
|
RU2627472C1 |
| METHOD FOR FORECASTING PRETERM LABOUR IN PRESENCE OF UROGENITAL INFECTION | 2006 |
|
RU2334233C1 |
| METHOD OF PREDICTING RISK OF MISCARRIAGE IN FIRST HALF OF PREGNANCY | 2014 |
|
RU2566728C2 |
| METHOD FOR PREDICTING PREMATURE BIRTH IN WOMEN WITH ISTHMIC-CERVICAL INSUFFICIENCY | 2021 |
|
RU2779363C1 |
| METHOD OF ASSESSING INNATE IMMUNITY IN CHILDREN WITH BRONCHIAL ASTHMA | 2016 |
|
RU2618410C1 |
| METHOD FOR PREDICTING PREMATURE BIRTH AND INTRAUTERINE INFECTION | 2011 |
|
RU2486519C1 |
| METHOD FOR EARLY PREDICTION OF HABITUAL MISCARRIAGE | 2014 |
|
RU2592204C1 |
| METHOD FOR PREDICTING PRETERM BIRTH | 2022 |
|
RU2783672C1 |
