METHOD FOR PREDICTING PRETERM BIRTH Russian patent published in 2022 - IPC G01N33/569 C12Q1/6851 C12Q1/689 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics, and can be used to predict preterm birth. The bacterial mass is taken and analyzed by the Femoflor-16 test system. Smear analysis with the Femoflor-16 test system is carried out at 10-14 weeks of pregnancy. From the data obtained, the total bacterial mass and indicators of microbiological analysis are isolated: Lactobacillus spp., Gardnerella vaginalis + Prevotella bivia + Poiphyromonas spp., Eubacterium spp., Sneathia spp. + Leptotrichia spp. + Fusobacterium spp., Lachnobacterium spp. + Clostridium spp., Mobiluncus spp/Corynebacterium spp., Ureaplasma spp., Staphylococcus spp. Based on their values, the PBIMA prognostic index is calculated using the formula

PBIMA =0.25-0,49X₁+0.74X₂-0.16X₃-0.22X₄-

-0.04X₅-0.22X₆-0.03X₇-0.03X₈+0.3X₉,

where X₁ - total bacterial mass, Lg GE/ml, X₂ - Lactobacillus spp., Lg GE/ml, X₃ - Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., Lg GE/ml, X₄ - Eubacterium spp., Lg GE/ml, X₅ - Sneathia spp. + Leptotrichia spp. + Fusobacterium spp., Lg GE/ml, X₆ - Lachnobacterium spp. + Clostridium spp., Lg GE/ml, X₇ - Mobiluncus spp/Corynebacterium spp., Lg GE/ml, X₈ - Ureaplasma spp., Lg GE/ml, X₉ - Staphylococcus spp., Lg GE/ml. If the PBIMA index is greater than 0, the risk of preterm birth is low, and if the PRIMA index is less than 0, the risk is high.

EFFECT: method provides the possibility of increasing the efficiency of predicting preterm labor in a pregnant woman in the first trimester by assessing the vaginal microbiocenosis by the CPR method with real-time detection of results using the Femoflor-16 test system.

1 cl, 5 dwg, 2 tbl, 2 ex