FIELD: medicine, pharmacy.
SUBSTANCE: conjugate includes a protein-based recognition molecule (PBRM) and a polymer carrier substituted with one or more -LD-D, at that, the protein-based recognition molecule is coupled with the polymeric carrier via LP. In each case of presence D is an independent therapeutic agent having a molecular weight of ≤5 kDa. LDand LP represent connecting links for therapeutic agent and PBRM coupling with the polymeric carrier, respectively. Furthermore, polymer frame structures used for conjugation with PBRM to form the described polymer-drug-PBRM conjugate; compositions containing the conjugates; methods for their production and methods for various disorders treatment using the conjugates or compositions thereof are disclosed.
EFFECT: invention refers to a drug conjugate.
28 cl, 8 dwg, 11 tbl, 80 ex
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