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IPC

A61K33/06(2006-01-01)

A61K33/16(2006-01-01)

C01F11/22(2006-01-01)

(21) (22)

Application

2014150120, 2014-12-10

(24)

Start date

2014-12-10

(22)

Actual filing date

2014-12-10

(45)

Published

2017-05-17

(72)

Inventor

Krylova Lidiya ValerevnaSannikova Natalya EvgenevnaBorodulina Tatyana ViktorovnaLevchuk Larisa Vasilevna

(73)

Holder

Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Professionalnogo Obrazovaniya Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhraneniya Rossijskoj Federatsii" Vpo Ugmu Minzdrava Rossii)

PRODUCTION PROCESS OF BIOACTIVE CALCIUM FLUORIDE AND METHOD OF ITS USE FOR PREVENTION AND TREATMENT OF FLUORINE DEFICIENCY CONDITIONS IN CHILDREN AND ADOLESCENTS Russian patent published in 2017 - IPC A61K33/06 A61K33/16 C01F11/22

Abstract RU 2619738 C2

FIELD: medicine.

SUBSTANCE: production process of high purity calcium fluoride, which comprises the step of reacting the calcium compound with hydrofluoric acid under stirring, separation by filtration of calcium fluoride precipitate, its drying . The starting reactants are 5-13% solutions of calcium chloride and 20% hydrofluoric acid, taken with a 20% excess of stoichiometry, mixing is performed at room temperature at a speed of 600-1000 rpm for 30 min. The bioavailability after oral administration is carried out by using galenic forms.

EFFECT: process allows to increase the biological activity of calcium fluoride by increasing its dispersion to 1,0-0,1 microns to form a stable suspension suitable for prevention and treatment of fluorine deficiency conditions in children and adolescents.

1 tbl, 4 dwg

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RU 2 619 738 C2

Authors

Krylova Lidiya Valerevna

Sannikova Natalya Evgenevna

Borodulina Tatyana Viktorovna

Levchuk Larisa Vasilevna

Dates

2017-05-17—Published

2014-12-10—Filed