METHOD FOR LOCALIZED METAPHYSEAL CHRONIC OSTEOMYELITIS SIMULATION IN RABBIT Russian patent published in 2017 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: to examine the characteristics of the osteomyelitis course, formulate and evaluate the effectiveness of various methods of treatment, the localized metaphyseal chronic osteomyelitis is simulated in a rabbit. In the area of the proximal metaepiphysis of the tibia, a bone defect is formed where a previously prepared sterile haemostatic sponge is placed with size corresponding to the defect size. After that, it is infected by introduction of a 0.5 microbial suspension of a daily culture of Staphylococcus aureus, containing 106 Cfu/ml. Then the wound is sutured and the animal is kept under normal conditions for at least 21 days.

EFFECT: creation of a localized focus of chronic metaphyseal osteomyelitis due to arrested bleeding and restricted spread of the infecting agent to adjacent segments, which leads to a low risk of infectious process generalization and lethal outcomes development for the experimental animal as a result of sepsis.

6 dwg, 1 ex