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2 623 877

(13)

(51)

IPC

A61K31/496(2006-01-01)

A61K47/20(2006-01-01)

A61K47/32(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2016131929, 2016-08-04

(24)

Start date

2016-08-04

(22)

Actual filing date

2016-08-04

(45)

Published

2017-06-29

(72)

Inventor

Solovskij Mikhail VasilevichBorisenko Maksim SergeevichSmirnova Marianna Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Vysokomolekulyarnykh Soedinenij Rossijskoj Akademii Nauk

METHOD FOR OBTAINING OF RIFAMPICINE POLYMERIC COMPLEXES WITH REDUCED TOXICITY AND HIGH ANTITUBERCULOSIS ACTIVITY Russian patent published in 2017 - IPC A61K31/496 A61K47/20 A61K47/32 A61P31/06

Abstract RU 2623877 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to medicine and is a method for production of rifampicine polymeric complexes with reduced toxicity and high antituberculosis activity by rifampicine complexing with anionic polyelectrolyte in its aqueous solution. Poly-2-acrylamido-2-methylpropanesulphonic acid with a molecular weight of 20,000-40,000 is used as an anionic polyelectrolyte, complexation is performed at a weight ratio of polymer:antibiotic equal to 1.9-4.0.

EFFECT: decreased rifampicin toxicity while preserving high level of anti-TB activity.

1 tbl, 4 ex

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RU 2 623 877 C1

Authors

Solovskij Mikhail Vasilevich

Borisenko Maksim Sergeevich

Smirnova Marianna Yurevna

Dates

2017-06-29—Published

2016-08-04—Filed