FIELD: medicine; biology.
SUBSTANCE: invention relates to a process for modified with sovialium gentamicin manufacture, which is applicable in biological and medical industries. Proposed method is based on the induction of aldehyde groups in the composition of sovial due to acid hydrolysis of acrolein unit and the formation of azomethine bonds between aldehyde groups of copolymer and deprotonated amino groups of gentamicin.
EFFECT: proposed method makes it possible to obtain a stable, prolonged antimicrobial action conjugate of gentamicin and soviale, formed due to azomethine bonds, capable of dissociating into the original components.
7 cl, 8 tbl, 4 dwg, 1 ex
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