FIELD: pharmacology.
SUBSTANCE: invention relates to a composition of bimatoprost and timolol containing no preservatives to reduce intraocular pressure in a human, containing the following composition: 0.03% w/o bimatoprosta; 0.5% w/o timolol; 0.268% w/o sodium phosphate dibasic heptahydrate; 0.014% w/o citric acid monohydrate; 0.68% w/o sodium chloride and water, and having a pH of 7.3. The invention provides a formulation that does not contain any antimicrobial preservative that is stable in solution for a long time at ambient temperature and is also stable in the plastic packaging in which it is usually stored.
EFFECT: compositions of the invention are more effective in treating increased IOP than compositions with preservatives, and have a lower risk of side effects.
8 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| IMPROVED BIMATOPROST OPHTHALMIC SOLUTION | 2006 |
|
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