OPHTHALMATIC COMPOSITIONS CONTAINING SUBSTITUTED GAMMA-LACTAMES AND METHODS OF THEIR APPLICATION Russian patent published in 2017 - IPC A61K9/00 A61K31/4025 A61P27/02 

FIELD: pharmacology.

SUBSTANCE: ophthalmic composition for ocular hypertension treatment comprises at least one therapeutically active agent in a concentration of 0.01 to 0.12% (w/v), at least one tonicity agent, glycerin or mannitol, a solubilizer-polysorbate 80 and a preservative- benzalkonium chloride. The therapeutically active agent has the structure where X¹ and X² independently represent CH₂, O or S, and R₁ is H or C₁-C₆ alkyl.

EFFECT: application of a group of inventions allows to increase the efficiency of ocular hypertension treatment due to a novel combination of ingredients of the composition where the active agent solubility is increased.

19 cl, 8 tbl, 10 ex