FIELD: pharmaceutics.
SUBSTANCE: present invention relates to a nano-aluminum-particle for the use in a vaccine composition. The nano-aluminum-particle contains: (a) suitable aluminum salt, where aluminum salt is selected from a group consisting of aluminum hydroxide, aluminum hydroxide gel, AlPo4, AlO(OH), Al(OH)(PO4) and Kal(SO4)2; and (b) suitable size-regulating agent, where size-regulating agent is selected from a group including polyacrylic acid (PAA), PEG, PEG connected to lipid, chitosan, dextran or polyallylamine; wherein the size of the specified particle is in the range from approximately 1 nm to approximately 450 nm. A method for producing nano-aluminum-particle, a composition for the use in the vaccine composition, a method for stimulating an immune response in a subject are also proposed.
EFFECT: proposed nano-aluminum-particles are stable and amenable to the final sterilization stage before being introduced into vials.
25 cl, 47 dwg, 15 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION CONTAINING TLR AGONIST AND METHODS FOR ITS APPLICATION | 2017 |
|
RU2761870C2 |
| PEGYLATED LIPOSOMES AND THEIR APPLICATION METHODS | 2017 |
|
RU2796539C2 |
| NANOSTRUCTURED LIPID CARRIERS AND STABLE EMULSIONS AND APPLICATIONS THEREOF | 2018 |
|
RU2816240C2 |
| EMULSIONS OF “OIL-IN-WATER” TYPE, WHICH CONTAIN NUCLEIC ACIDS | 2012 |
|
RU2606846C2 |
| CATIONIC OIL-IN-WATER EMULSIONS | 2012 |
|
RU2649133C2 |
| SMALL LIPOSOMES FOR DELIVERY OF IMMUNOGEN CODING RNA | 2011 |
|
RU2671482C2 |
| ANTICANCER RNA VACCINES | 2017 |
|
RU2768829C2 |
| PEGYLATED LIPOSOMES FOR IMMUNOUGEN-CODING RNA DELIVERY | 2012 |
|
RU2628705C2 |
| CATIONIC EMULSIONS "OIL-IN-WATER" | 2011 |
|
RU2625546C2 |
| COATING FOR AN INTRALUMINAL DIVERGENT CATHETER, PROVIDING CONTACT DELIVERY OF MICRORESERVOIRS WITH A DRUG PREPARATION | 2015 |
|
RU2721655C2 |
