LIQUID COMPOSITIONS OF RIFAXIMIN Russian patent published in 2024 - IPC A61K31/437 A61K47/10 A61K47/14 A61K47/22 A61K47/26 A61K9/08 A61K9/48 A61K9/52 A61P1/00 A61P1/16 A61P31/04 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, specifically to a pharmaceutical composition for treating disorders associated with intestine or liver function. Disclosed is a pharmaceutically acceptable composition for treating disorders associated with intestine or liver function, where the composition contains rifaximin, from 25 to 50 wt.% of hydrogenated castor oil and from 45 to 65 wt.% of at least one additional solubilizing excipient, selected from castor oil, glyceryl caprylate, polysorbate 80, diethyl sebacate, diethylene glycol monoethyl ether and combinations thereof. Also disclosed is a method of treating one or more disorders associated with intestinal or liver function in a subject in need thereof, comprising a step of administering to the subject a therapeutically effective amount of the pharmaceutical composition.

EFFECT: composition described above is stable, characterized by improved availability of soluble rifaximin in stomach, small intestine and/or large intestine.

61 cl, 11 dwg, 11 tbl