STERINES DERIVATIVES AND THEIR APPLICATION FOR TREATMENT OF DISEASES RELATED TO TRANSFORMED ASTROCYTAL CELLS, OR FOR TREATMENT OF MALIGNANT BLOOD DISEASES Russian patent published in 2017 - IPC C07J9/00 C07J17/00 C07J41/00 A61K31/575 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of formula

having a basic structure of 7 beta-hydroxycholesterol, where A is a group of -(R₁)_n, where R₁ is an amino acid residue of glycine or alanine attached to its C-terminus, and n is 1 or 2. Moreover, R₁ are the same or differentt and the N-terminus of the said amino acid is substituted with -C(O)-R₂, where R₂ is a benzyloxy group or a -(R₁)_n group, where R₁ is an amino acid residue of glycine or alanine, n is 1 or 2, and the N-terminus of the said amino acid is substituted with benzyloxycarbonyl; or -C(O)-R₆ group, where R6 is a five-member heterocycle comprising 2 oxygen heteroatoms unsubstituted or substituted with at least one unbranched or branched C₁-C₆alkyl; B is a -C(O)-R₇ group, where R₇ is C₁-C₆alkyl, unbranched or branched; or R₇ is OR₈, where R₈ is C₁-C₆alkyl unbranched or branched. The invention also relates to individual compounds, a process for the preparation of a formula (I) compound, and a pharmaceutical composition having activity against transformed astrocyte cells.

EFFECT: new compounds of the formula are obtained that can be used to treat diseases associated with transformed astrocytes.

15 cl, 4 tbl, 16 ex