METHOD FOR OBTAINING AROMATIC OR FATTY-AROMATIC KETONES (VARIANTS) Russian patent published in 2017 - IPC C07C49/786 C07C49/784 C07C49/807 C07C49/813 C07C45/44 C07C49/84 C07C49/782 C07C49/788 C07D333/22 B01J31/22 

FIELD: chemistry.

SUBSTANCE: invention relates to processes of preparing aromatic or fatty-aromatic ketones by reaction of aromatic chlorides or bromides or iodides with an aliphatic or aromatic nitriles, including intramolecular reactions containing nitrile group of aromatic chlorides, bromides or iodides, initially resulting compound with bond C=N undergoes subsequent hydrolysis to form the desired product. In particular, a process of preparing aromatic or aliphatic-aromatic ketones of the general formula R₁C(O)R₂, where R₁ - aryl or hetaryl, and R₂ - aryl or hetaryl or alkyl comprises reacting aromatic halide R₁X, wherein R₁ - aryl or hetaryl, and X=Cl, Br, I with nitriles R₂CN, where R₂ - aryl or hetaryl, or alkyl, which is carried out in the presence of a catalyst comprising nickel atom coordinated with a chelate ligand containing 1,4-diazabutadiene fragment (N=C-C=N), and a reducing agent in an ether solvent at molar ratios: R₁X:R₂CN, located within the range of from 2:1 to 1:20, Ni:(chelating ligand) is located within the range of from 1:1 to 1:2, Ni:R₁X, is located in the range of from 1:200 to 1:2, the reducing agent: R₁X, is located in the range of from 1:2 to 10:1, and the volume of the solvent with respect to the amount of the halide R₁X is in the range of 0.5 to 20 ml/mmol, at a reaction temperature of 0-120°C, and the subsequent hydrolysis of the initially formed compound with the connection of C=N.

EFFECT: expansion of the arsenal of tools, the use of compounds as starting aryl bromides and aryl chlorides, cheaper and more readily available; use of at least twice lower catalyst loads; possibility of carrying out the reaction at a lower temperature; the possibility of carrying out the reaction in a shorter time.

18 cl, 40 ex