FIELD: biotechnology.
SUBSTANCE: in order to suppress the growth of multidrug resistant strains of Mycobacterium tuberculosis, a photodynamic effect is carried out in the experiment. As a photosensitizer, photoditazine at a concentration of 4⋅10-5 Mol/l. The irradiation is carried out with a low-intensity Azor-2K-02 laser with a wavelength of 660 nm, an output power of 25 mW emitting in a constant mode for 40 minutes at a power density of 0.32 mW/cm2 And an energy density of 0.76 J/cm2.
EFFECT: method provides simple, reliable and effective inhibition of the growth of mycobacterium tuberculosis culture due to an additional inhibitory effect and enhancement of the bacteriostatic effect of laser irradiation of the cell culture treated with a photosensitizer.
1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT EXHIBITING BACTERIOSTATIC ACTIVITY ON MULTIRESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS IN EXPERIMENT | 2015 |
|
RU2602450C1 |
| METHOD FOR INACTIVATION OF DRUG-SENSITIVE AND DRUG-RESISTANT STRAINS OF MYCOBACTERIUM TUBERCULOSIS IN EXPERIMENTAL CONDITIONS IN VITRO | 2018 |
|
RU2702646C1 |
| HYDROGEL COMPOSITION FOR TREATING INVESTING TISSUE DEFECTS BY PHOTODYNAMIC THERAPY | 2020 |
|
RU2730850C1 |
| METHOD OF TREATING PLEURAL EMPYEMA | 2017 |
|
RU2661090C1 |
| METHOD OF OPTIMISATION OF PHOTODYNAMIC THERAPY OF PURULENT WOUNDS (VERSIONS) | 2015 |
|
RU2609735C1 |
| METHOD FOR PHOTODYNAMIC THERAPY OF LEFT TUMORS OF MICE EHRLICH CARCINOMA WITH CHLORINE SERIES PHOTO-SENSITIZER | 2022 |
|
RU2788766C2 |
| METHOD FOR GROWTH INHIBITION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAIN | 2015 |
|
RU2598272C1 |
| METHOD FOR ASSESSING ANTI-HERPETIC EFFICACY in vitro OF PHOTODYNAMIC EXPOSURE ON HERPES SIMPLEX VIRUS (HSV) | 2013 |
|
RU2529792C1 |
| METHOD OF TREATING PATIENTS WITH CHRONIC RECURRENT BACTERIAL CYSTITIS | 2023 |
|
RU2820135C1 |
| PHOTOSENSITIZING AGENTS FOR PHOTODYNAMIC THERAPY | 2005 |
|
RU2282646C1 |
