FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to a method of producing 9-aroyl-8-hydroxy-6-(2-hydroxyaryl)-3-phenyl-1,3,6-triazaspiro[4.4]non-8-ene-2,4,7-triones of formula IIa-b by reacting 3-aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones Ia-b with phenylurea, carried out by holding the reagents at room temperature in ethyl acetate according to the following scheme:
,
where I and II: Ar=C6H4Br-4 (a); Ar=C6H4Me-4 (b).
EFFECT: method of producing novel compounds which can be used as starting products for synthesis of novel heterocyclic systems and in medicine as agents having antimicrobial activity.
1 cl, 1 tbl, 3 ex
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Year |
Author |
Number |
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