FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a bisphosphonic acid compound represented by following formula (1) or a pharmaceutically acceptable salt thereof:
.
In formula (1): ------ is a single bond or double bond, A is a saturated cyclic hydrocarbon C3–8 (saturated cyclic hydrocarbon is optionally substituted with 1–4 groups selected from a group consisting of a C1–6-alkyl group, C6–10-aryloxy groups and halogen atoms), R1 and R2 each independently represent a C1–6-alkyl group, a halogen atom or a hydrogen atom. Also disclosed is a pharmaceutical composition, a preventive or therapeutic drug for treating a disease associated with ectopic calcification, use of the compound of formula (1) and a method for preventing or treating a disease associated with ectopic calcification.
EFFECT: disclosed compound of the present invention or salt thereof excellently inhibits ectopic calcification.
7 cl, 7 tbl, 62 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF OLIGOSACCHARIDES | 2004 |
|
RU2290408C2 |
| ARGINASE INHIBITORS AND THERAPEUTIC USE THEREOF | 2011 |
|
RU2586219C2 |
| PRODRUG OF FLUORINE-CONTAINING AMINO ACID | 2013 |
|
RU2639868C1 |
| BORONIC ACID DERIVATIVES | 2015 |
|
RU2717558C2 |
| 1-METHYLCARBAPENAM DERIVATIVES | 2001 |
|
RU2247725C2 |
| DERIVATIVES OF CYCLOPROPYL-β-AMINO ACID | 2004 |
|
RU2312853C2 |
| 1-METHYLCARBAPENEM OR ITS PHARMACOLOGICALLY ACCEPTABLE SALTS, COMPOSITION, METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENT WITH BACTERIAL INFECTION | 1997 |
|
RU2162088C2 |
| DERIVATIVES OF DOLASTATIN 10 | 2002 |
|
RU2296750C2 |
| 4-ISOPROPYLPHENYLGLUCITE DERIVATIVES AS SGLT1 INHIBITORS | 2010 |
|
RU2518896C2 |
| 2-PYRIDONE DERIVATIVES | 2010 |
|
RU2551847C2 |
