IONIC SILOCONE HYDROGELS WITH IMPROVED HYDROLYTIC STABILITY Russian patent published in 2017 - IPC G02B1/04 C08F290/06 G02C7/04 

FIELD: chemistry.

SUBSTANCE: contact lens is proposed, formed by polymerizing a composition containing, at least, one silicone-containing component and, at least, one ionic component having, at least, one carboxylic acid group at the concentration of up to 9.3 mmol/100 g, wherein the said components are present in molar concentrations providing a product of stability less than 0.0006, and the ionic component is present in the polymer in the concentration of 0.05 to 0.8 wt %. The ionic component is selected from the group consisting of acrylic, methacrylic, fumaric, maleic, itaconic, crotonic, cinnamic and vinylbenzoic acids, monoesters of fumaric, maleic and itaconic acids and N-vinyloxycarbonylalanine (N-vinyloxycarbonyl-β-alanine), as well as their homopolymers and copolymers. The silicone-containing component is selected from compounds of formula I , wherein b=2-20; at least, one terminal group R¹ is a monovalent reactive group, and the other terminal group R¹ is a monovalent reactive group or a monovalent alkyl group containing 1 to 16 carbon atoms, the remaining R₁ groups are independently selected from monovalent alkyl groups having 1 to 16 carbon atoms. The proposed contact lens absorbs, at least, 10 μg of lysozyme, less than 5 μg of lipocalin, and, at least, 50% of all proteins absorbed in or on the surface of the said contact lens are in the native form.

EFFECT: proposed lenses demonstrate a balance of the desired level of protein absorption, compatibility with existing solutions for contact lens care and thermal stability.

18 cl, 5 dwg, 13 tbl, 18 ex