COMPOSITIONS FOR PREVENTION OR TREATMENT OF LUPUS Russian patent published in 2021 - IPC A61K31/397 A61K31/5375 A61K31/5377 A61K31/496 A61P43/00 C07D401/12 

FIELD: medicine.

SUBSTANCE: presented group of inventions relates to the field of medicine and pharmaceuticals, namely to an application of a compound represented by the formula I or a pharmaceutically acceptable salt thereof in an effective amount for prevention or treatment of lupus: wherein A constitutes , each of Xa and Xb independently constitutes CH, each of L₁ and L₂ independently constitutes hydrogen or halogen, Q constitutes C(=O), Y is selected from the following group: , M constitutes C, N or O, wherein in this case, when M constitutes C, l and m equal 1; when M constitutes N, l equals 1 and m equals 0; and when M constitutes O, l and m equal 0, each of R_a1 and R_a2 independently constitutes hydrogen; -C_1-4 alkyl with a straight or branched chain; or halogen; n constitutes an integer equal to 0, 1 or 2, R_b constitutes hydrogen; Z is selected from the following group: , each of P_a and P_b independently constitutes hydrogen; -C_1-4 alkyl with a straight or branched chain, wherein said alkyl is unsubstituted or no less than one hydrogen atom is substituted with halogen; halogen; or -CF₃. Also described is a method for treating lupus, including introducing a therapeutically effective amount of the compound represented by the following formula I, or a pharmacologically acceptable salt thereof, as well as an application of the compound represented by the following formula I, or a pharmacologically acceptable salt thereof for producing a medicinal product for treating lupus.

EFFECT: ensured application of compounds exhibiting an excellent effect in preventing or treating lupus.

[Formula I]

10 cl, 21 dwg, 4 tbl, 15 ex