FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to oncology, and concerns therapy of intestinal adenoma and/or adenocarcinoma by Notch inhibition. That is ensured by introduction of a γ-secretase inhibitor or a based pharmaceutical composition in the effective amount.
EFFECT: effective therapy enabled due to differentiation of adenoma and/or adenocarcinoma cells into goblet cells.
20 cl, 1 tbl, 6 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| BARRETT'S OESOPHAGUS THERAPY | 2006 |
|
RU2432163C2 |
| CULTURE MEDIUM FOR STEM CELLS | 2012 |
|
RU2714256C2 |
| IMPROVED DIFFERENTIATION METHOD | 2017 |
|
RU2772435C2 |
| CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS, CONTAINING THEREOF | 2010 |
|
RU2555545C2 |
| LIVER ORGANOID, VERSIONS OF USE THEREOF AND CULTURE METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2579995C2 |
| INHIBITORS OF NOTCH SIGNAL TRANSMISSION WAYS AND THEIR APPLICATION FOR CANCER TREATMENT | 2012 |
|
RU2631611C2 |
| DOUBLE TUBULAR STRUCTURES | 2017 |
|
RU2756404C1 |
| METHODS FOR TREATING MALIGNANT TUMOUR WITH APPLICATION OF NOTCH SIGNAL TRANSDUCTION PATHWAY INHIBITORS | 2008 |
|
RU2584579C2 |
| METHOD FOR TISSUE REGENERATION STIMULATION | 2007 |
|
RU2480213C2 |
| ANTIBODIES AGAINST NOTCH2 AND METHODS FOR APPLICATION THEREOF | 2009 |
|
RU2580029C2 |
