DERIVATIVES OF 6,7-DOUBLE SUBSTITUTED IZOCHINOLIN AND THEIR APPLICATION IN TREATMENT OF MEDICINAL DEPENDENCE AND CNS DISEASES Russian patent published in 2017 - IPC C07D217/02 C07D217/22 A61K31/47 A61P25/16 A61P25/28 A61P25/30 

FIELD: pharmacology.

SUBSTANCE: invention relates to an isoquinoline derivative of the general formula

and to a pharmaceutically acceptable salt thereof a dotted bond is denoted as a possible bond; R' is H or absent, and the dotted bond is denoted as a bond; R1 and R4 are each independently selected from the group including H, halogen; R2 and R3 are both F or R2 or R3 is F, then the other radical is a lower alkyl or trifluoromethyl; and R5 is selected from the group including halogen, or when the dotted bond is denoted as a bond, then R5 can also be represented as H; with the exception of 6,7-difluoro-1,2,3,4-tetrahydro-1-methyl-isoquinoline. The invention also relates to a pharmaceutical composition based on a compound according to p.1 or 6,7-difluoro-1,2,3,4-tetrahydro-1-methyl-isoquinoline and their application.

EFFECT: compounds have been obtained which are useful in the treatment of drug dependence, alcoholism or diseases of the central nervous system.

13 cl, 5 ex