FIELD: veterinary medicine.
SUBSTANCE: vaccine composition includes a structure containing an O-antigen obtained from Salmonella as an active ingredient, provided that the said structure does not contain an entire cell, the said structure containing O-antigen is a lipopolysaccharide containing Lipid A. The method of the invention concerns obtaining of a vaccine composition, and comprises the steps of: gram-negative bacteria culturing, release of the above-mentioned structure from cells, collection and preparation of a solution of an O-antigen-containing structure.
EFFECT: reduces inoculation reaction and reduces the amount of injection compared to the usual whole-cell vaccine.
14 cl, 2 tbl, 6 dwg, 2 ex
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