ENANTIOMERS-2-HYDROXY-DERIVATIVES OF FATTY ACIDS Russian patent published in 2017 - IPC C07C59/42 A61K31/19 A61P3/04 A61P3/06 A61P3/10 A61P35/00 A61P35/02 A61P9/00 A61P9/10 A61P9/12 

FIELD: pharmacology.

SUBSTANCE: invention relates to the enantiomer [-] of the formula: [-]NaOOC-HOCH-(CH₂)₆-(CH=CH-CH₂)₁-(CH₂)₆-CH₃ and a pharmaceutical composition for treatment of a pathology caused by an abnormally low level of sphingomyelin and/or an abnormally high level of dihydrofolate reductase (DGFR) containing a therapeutically effective amount of an enantiomer of the following formula: [-]HOOC-HOCH-(CH₂)₆-(CH=CH-CH₂)₁-(CH₂)₆-CH₃ and/or at least one of its pharmaceutically acceptable salts and, optionally, a pharmaceutically acceptable carrier. The invention also relates to a method for treatment of pathologies, the common etiology of which is an abnormally low level of sphingomyelin, and/or an abnormally low level of glycophelial acid protein (GPAP) and/or an abnormally high level of dihydrofolate reductase (DHFR), comprising administration of a therapeutically effective amount of the enantiomer of the following formula: [-]HOOC-HOCH-(CH₂)₆-(CH=CH-CH₂)₁-(CH₂)₆-CH₃ and/or at least one of its pharmaceutically acceptable salts or composition comprising the said enantiomer and/or at least one of its pharmaceutically acceptable salts to the patient.

EFFECT: increased efficiency of treatment.

9 cl, 10 dwg, 5 tbl, 9 ex