FIELD: biotechnology.
SUBSTANCE: invention is intended for determination of tumour B lymphoblasts availability markers to establish the primary structure of the major immunoglobulin heavy chain genes. The absence of major products of BCR locus amplification indicates the absence of tumour B-lympholasts. In case of predominance of B-lymphoblasts clones with rearrangements, minimal residual disease is determined in acute leukemia in children.
EFFECT: effective detection of the genes type of the immunoglobulins heavy chain and establishment of the primary structure of the rearranged gene.
1 dwg, 1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD FOR DETERMINING MARKERS OF PRESENCE OF TUMOR T-LYMPHOBLASTS |
2016 |
- Lebedev Yurij Borisovich
- Mamedov Ilgar Ziyaddinovich
- Shcheglov Aleksandr Sergeevich
- Minervina Anastasiya Alekseevna
|
RU2674994C2 |
| METHOD FOR DETERMINING MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN CHILDREN AND ADULTS WITH B-LINEAR ACUTE LYMPHOBLASTIC LEUKEMIA IN CONDITIONS OF CD19-DIRECTED IMMUNOTHERAPY |
2022 |
- Mikhailova Ekaterina Valerevna
- Popov Aleksandr Mikhailovich
- Illarionova Olga Ivanovna
- Semchenkova Aleksandra Aleksandrovna
- Maschan Mikhail Aleksandrovich
- Novichkova Galina Anatolevna
|
RU2818950C1 |
| METHOD FOR DETECTION OF STRUCTURAL REARRANGEMENTS OF TUMOR CELLS (CHEMERIC GENES) GENOME, DETERMINING SELECTION OF THERAPY AND PREDICTION IN ACUTE LEUKOSIS IN CHILDREN, USING OT-PCR AND SUBSEQUENT HYBRIDIZATION WITH OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) |
2016 |
- Ikonnikova Anna Yurevna
- Fesenko Denis Olegovich
- Karateeva Anna Vladimirovna
- Zasedatelev Aleksandr Sergeevich
- Nasedkina Tatyana Vasilevna
|
RU2639513C1 |
| RECOMBINANT PLASMID pAL2-T-WBMAG DNA, USED FOR CREATION OF DNA-CALIBRATORS AT THERAPY EFFICIENCY ASSESSMENT FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA |
2017 |
- Potter Alisa Yanovna
- Barkhatov Ildar Munerovich
- Shakirova Alena Igorevna
- Chukhlovin Aleksej Borisovich
- Afanasev Boris Vladimirovich
|
RU2642315C1 |
| METHOD FOR DIAGNOSING ACUTE LEUKEMIA AND KITS FOR ITS IMPLEMENTATION |
2021 |
- Olkhovskij Igor Alekseevich
- Gorbenko Aleksej Sergeevich
- Stolyar Marina Aleksandrovna
- Komarovskij Yurij Yurevich
- Tyumentseva Anna Vladimirovna
|
RU2806591C2 |
| RECOMBINANT PLASMID DNA PAL2-T-EXP, USED TO CREATE DNA CALIBRATORS IN EVALUATING THE EFFECTIVENESS OF THERAPY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA |
2017 |
- Potter Alisa Yanovna
- Barkhatov Ildar Munerovich
- Izmajlova Ekaterina Andreevna
|
RU2670543C1 |
| METHOD OF DIAGNOSING ONCOLOGICAL DISEASES OF THE BLOOD |
2022 |
- Nikitaev Valentin Grigorevich
- Pronichev Aleksandr Nikolaevich
- Nagornov Oleg Viktorovich
- Tupitsyn Nikolaj Nikolaevich
- Selchuk Vladimir Yurevich
- Dmitrieva Valentina Viktorovna
- Palladina Aleksandra Dmitrievna
- Polyakov Evgenij Valerevich
|
RU2803281C1 |
| SET OF OLIGODEOXYRIBONUCLEOTIDE PRIMERS AND FLUORESCENTLY LABELED DNA PROBES FOR DETERMINING THE EXPRESSION OF THE SOCS2, CD34, FAM30A, GPR56, DNMT3B, SPINK2 GENES, FOLLOWED BY DETERMINING THE LEVEL OF RELATIVE EXPRESSION RELATIVE TO THE ABL1 REFERENCE GENE, AMPLIFIED IN REAL-TIME PCR, USED TO PREDICT THE RISK OF EARLY RELAPSE IN CHILDREN WITH ACUTE MYELOID LEUKEMIA AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION |
2022 |
- Rakhmanova Zhemal Zarifovna
- Sadykov Ajrat Maratovich
- Semenova Elena Vladimirovna
- Barkhatov Ildar Munerovich
|
RU2783950C1 |
| METHOD FOR IDENTIFYING CHROMOSOMAL TRANSLOCATIONS LEADING TO THE DEVELOPMENT OF MALIGNANT BLOOD DISEASES (LEUKOSES), DUE TO APPLYING OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) |
2004 |
- Mirzabekov Andrej Dar'Evich
- Nasedkina Tat'Jana Vasil'Evna
- Zharinov Vladislav Sergeevich
- Isaeva Ekaterina Aleksandrovna
|
RU2286798C2 |
| METHOD OF ANALYSIS OF SOMATIC MUTATIONS IN THE BCR/ABL CHIMERIC GENE USING RT-PCR AND SUBSEQUENT HYBRIDIZATION WITH OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) |
2015 |
- Ikonnikova Anna Yurevna
- Nasedkina Tatyana Vasilevna
- Zasedatelev Aleksandr Sergeevich
|
RU2609641C1 |
